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Kungakhona yini kuhlolwa kwemchamo lokulula kutfola sifo se-Alzheimer lesisesigabeni sekucala, lokuvule indlela yetinhlelo tekuhlola bantfu labanyenti? Sifundvo lesisha se-Frontiers ku-Neuroscience yekuguga sikhombisa loku ngalokucinisekile. Labacwaningi bahlola licembu lelikhulu letigulane te-Alzheimer letinebukhulu lobehlukahlukene kanye nebantfu labanemphilo lebebavamile ngekwengcondvo kute babone umehluko kuma-biomarkers emchamo.
Batfola kutsi i-formic acid emchameni iyinkhomba lebucayi yekwehla kwengcondvo futsi ingamemetela tigaba tekucala tesifo se-Alzheimer. Tindlela letikhona tekuhlola sifo se-Alzheimer tiyabita, atikalungi, futsi ativumeleki kutsi tihlolwe njalo. Loku kusho kutsi tigulane letinyenti tihlolwa kuphela uma sekwephutile kakhulu kutsi tingakwelashwa ngemphumelelo. Kepha, kuhlolwa kwemchamo lokungahlaseli, lokungabiti, futsi lokukahle kwe-formic acid kungaba ngiko kanye bodokotela labakucelako kutsi bahlolwe kusenesikhatsi.
Lababhali batsi: “Sifo se- Alzheimer sifo lesingapheli lesiphikelelako futsi lesinebucili, lokusho kutsi singavela futsi siphikelele iminyaka leminyenti ngaphambi kwekutsi kuvele kukhubateka kwengcondvo lokusobala.” "Tigaba tekucala talesifo tenteka ngaphambi kwesigaba sekugula ngengcondvo lokungabuyiselwa emuva, lokulifasitelo leligolide lekungenelela nekwelapha. Ngako-ke, kuhlolwa kwesifo se-Alzheimer lesisesigabeni sekucala kubantfu labadzala ngesilinganiso lesikhulu kuyadzingeka."
Ngako-ke, nangabe kungenelela kusenesikhatsi kubalulekile, kungani singenato tinhlelo tekuhlola letijwayelekile tesifo se-Alzheimer lesisesigabeni sekucala? Inkinga ilele etindleleni tekuhlola bodokotela labatisebentisako nyalo. Loku kufaka ekhatsi i- positron emission tomography yengcondvo, lebita kakhulu futsi lefaka tigulane emisebeni. Kukhona nekuhlolwa kwe biomarker lokungabona i-Alzheimer, kepha kudzinga kudvonswa kwengati lokuhlaselako noma kubhobota lumbar kutfola lutfuli lwebuchopho, lokungenteka tigulane tibekelwe eceleni.
Nomakunjalo, kuhlolwa kwemchamo akuhlaseli futsi kulula, kwenta kutsi kube kuhle kakhulu ekuhlolweni kwebantfu labanyenti. Noma nje bacwaningi sebabone ngaphambilini ema biomarkers emchamo esifo se Alzheimer, kute lafanele kutfola tigaba tekucala talesifo, lokusho kutsi lifasitelo leligolide lekwelashwa kwekucala lihlala lingabonakali.
Labacwaningi labasemuva kwalolucwaningo lolusha bake bafundza ngetintfo letiphilako letibitwa ngekutsi yi-formaldehyde njenge-biomarker yemchamo yesifo se-Alzheimer. Kepha, kunendzawo yekutfutfuka ekutfoleni tifo kusenesikhatsi. Kulolucwaningo lwakamuva, bagcile ku formate, i-formaldehyde metabolite, kute babone kutsi isebenta kancono yini njenge-biomarker.
Bantfu labangu-574 babamba indzaba kulolucwaningo, futsi labahlanganyeli bebangemavolontiya laphilile lavamile ngekwengcondvo noma bebanemazinga lehlukahlukene ekuchubeka kwesifo, kusuka ekuncipheni kwengcondvo lokungekho emtsetfweni kuya ekuguleni lokuphelele. Labacwaningi bahlatiya umchamo kanye nemasampula engati kulabahlanganyeli futsi benta luhlolo lwengcondvo.
Lucwaningo lutfole kutsi emazinga e-formic acid emchameni aphakeme kakhulu kuwo onkhe emacembu esifo se-Alzheimer futsi ahambisana nekwehla kwengcondvo uma kucatsaniswa nekulawula lokunemphilo, kufaka ekhatsi licembu lekucala lekwehla kwengcondvo le-subjective. Loku kusikisela kutsi i-formic acid ingasebenta njenge-biomarker lebucayi yetigaba tekucala tesifo se-Alzheimer.
Kuyatsakatelisa kutsi ngesikhatsi labacwaningi bahlatiya emazinga e- formate emchameni ngekuhlanganiswa nema- biomarkers engati ye- Alzheimer, batfola kutsi bangakhona kubiketela kahle sigaba sesifo lesibhekene naso. Kepha, kudzingeka lucwaningo lolunye kute kucondvwe kuchumana emkhatsini wesifo se-Alzheimer ne-formic acid.
Lababhali batsi: “I- formic acid yemchamo ikhombise kuzwela lokuhle kakhulu kute kusheshe kuhlolelwe sifo se- Alzheimer.” “Kuhlolwa kwemchamo nge- biomarker yesifo se- Alzheimer kulula futsi akubiti futsi kufanele kufakwe ekuhlolweni kwemphilo lokuvamile kwebantfu labadzala.”
Wang, Y. kanye nalabanye. (2022) Kubuyeketwa lokuhlelekile kwe-formic acid yemchamo njenge-biomarker lensha lengaba khona yesifo se-Alzheimer. Imingcele ku-neurobiology yekuguga. 10.3389/fnagi.2022.1046066.
Emathegi: kuguga, sifo se-Alzheimer, ema-biomarkers, ingati, ingcondvo, tifo letingapheli, letingapheli, emakhompawundi, kugula kwengcondvo, kuhlola, bodokotela, i-formaldehyde, i-neurology, i-tomography yekukhishwa kwe-positron, lucwaningo, i-tomography, kuhlatiya umchamo
Ku-Pittcon 2023 ePhiladelphia, ePennsylvania, sakhulumisana naSolwazi Joseph Wang, lophumelele Umklomelo waRalph N. Adams walomnyaka kuKhemikhali Yekuhlatiya, mayelana nekusebenta ngetindlela letinyenti kwebuchwepheshe be-biosensor.
Kule ngcoco, sicoca nge-biopsy yekuphefumula nekutsi ingaba njani lithulusi lelilusito lekufundza ema-biomarkers ekutfola sifo kusenesikhatsi naMariana Leal, Umholi Welicembu e-Owlstone Medical.
Njengencenye yekubuyeketwa kwetfu kwe-SLAS US 2023, sicoca nge-lab yelikusasa nekutsi ingabukeka kanjani naLuigi Da Via, Umholi Welicembu Lekutfutfukisa Kuhlolwa kwe-GSK.
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